What to Know About Abortion Pill Reversal?

January 22, 2026

Taking the first drug in a medical abortion, mifepristone, can lead to second thoughts. If you’re experiencing regret and wondering if there’s still a way to continue your pregnancy, you’re not alone. A protocol called Abortion Pill Reversal (APR) may be able to help. However, timing is critical.

Heart to Heart offers no-cost referrals and information to those who want to begin APR. Contact a nurse at Heart to Heart at (307) 745-3444.

You can also contact the Abortion Pill Reversal Helpline at 1-877-558-0333 for 24/7 support and help in finding a provider.

How Abortion Pill Reversal Works

A medical abortion typically involves two drugs taken at different times:

• Mifepristone, which blocks progesterone, a hormone needed to support pregnancy
• Misoprostol, which is taken afterward and causes uterine contractions that expel the pregnancy

The APR protocol involves administering progesterone under medical supervision in an effort to counteract the effects of mifepristone and support the pregnancy’s continuation.

Why Timing Matters

APR depends greatly on how quickly care begins. Starting progesterone within 24 to 48 hours after taking mifepristone is associated with higher rates of success, although results vary and cannot be guaranteed. In some cases, attempts have been made up to 72 hours after the first pill and even later, but it’s critical to start right away.

Once misoprostol has been taken, APR is not considered effective.

Safety and Effectiveness

Progesterone has been used in pregnancy care for more than 50 years, including for women at risk of miscarriage. 

Research examining its use for APR has not shown an increased risk of birth defects, and some studies have reported pregnancy continuation in roughly two-thirds of cases when treatment begins early.

Considering Your Next Steps

If you’ve taken the first abortion drug and want to explore the possibility of reversal, don’t wait to seek help. For urgent questions or time-sensitive support, call the Abortion Pill Rescue Network’s 24/7 Helpline at 1-877-558-0333.

Or you can contact a nurse at Heart to Heart at (307) 745-3444. Conversations are free, confidential, and offered in a nonjudgmental, pressure-free setting.

Time matters, and support is available.

Heart to Heart does not provide or refer for abortions.

All abortion information sourced in this blog is based on accurate information at the time of writing.